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KMID : 1137820220430040271
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의공학회지
2022 Volume.43 No. 4 p.271 ~ p.279
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Skin-Mimicking Phantom for Measurment of Cosmetic Transdermal Absorption and Temperature Changes by Sonophoresis
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Kim Ga-Hee
Jang Hwi-Jin
Choi Seon-Min
Park Sang-Hyo
Kim Woo-Cheol
Key Jae-Hong
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Abstract
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Functional cosmetics containing various ingredients that improve skin health are currently being developed. In addition, technologies that help increase the absorption rate of such cosmetics have recently gained significant attention. Sonophoresis is a method to increase the transdermal absorption of cosmetics using ultrasound. A skin- mimicking phantom was fabricated using polydimethylsiloxane, Strat-MTM membrane, and thermochromic pigments. Gel-type cosmetics used in skin mask packs and epidermal-growth-factor-based nano-cosmetics were tested for their absorption rates at ultrasound frequencies of 1, 3, and 10 MHz in the single frequency mode, and 1/3 and 3/10 MHz in the dual frequency mode. The gel-type cosmetics and epidermal-grow-factor-based nano-cosmetics showed the highest absorption rate at 3/10MHz dual frequency. The size of the cosmetic particles decreased by 5-9 %. Furthermore, the temperature rise caused by ultrasound could be visually recognized by the thermochromic pigment in the phantom turning white. We presented a skin-mimicking phantom. The device can be customized according to the size of the ultra- sound probe and has the advantage of quantitatively evaluating the transdermal permeability of cosmetics at a low cost. The development of the skin-mimicking phantom will be useful for determining the suitable conditions required to increase the absorption rate of cosmetics using ultrasound.
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KEYWORD
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Nano-cosmetic, Sonophoresis, Skin absorption, Skin-mimicking phantom
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